The Methylation Pathway – often if not usually this pathway is linked to chronic diseases, including autism.  By pathway we mean the system in the body that produces a product.   As one person put it (don’t know who)  the Methylation factory in our body, produces glutathione, like the Ford Factory produces pick up trucks.  The pathway also produces various other compounds, but glutathione is analogous to the big trucks because of its power.   But like a car or truck, there are a number of steps required to produce a finished product, the Methylation factory has lots of steps required before producing the finished product: glutathione.

Glutathione is hugely important to a huge number of required processes in the body that maintain and restore both physical health and mental health.   Children with autism tend to have lower levels of glutathione when compared to neurotypical children; as do people with schizophrenia, alcoholism, bi-polar disease, depression, attention deficit disorder, constipation, and autism.  In fact, almost every disease, dysfunction, or disorder has been associated with low levels of glutathione.   Glutathione is essential for protecting cells from toxins – it is not only our master anti-oxidant, but also a chelator, transporter, regulator, protector, detoxer, etc.  It is important to our cardiovascular, immune, respiratory and muscleskelal system and even seems to play a role in FOCUS, CONCENTRATION, AND LANGUAGE.

The additional challenge with glutathione is that we need it more than ever – and we are losing faster than ever!!!

We can actually increase our body’s ability to produce glutathione….even if we are genetically challenged!

We can turn on the body’s DNA to make the mRNA tools (mix masters) to produce glutathione; we can give the body the nutrients (like a pancake mix) to make the glutathione.  We can look at just the well known GSH (of the GSH-GSSG) component or we can look at all 8 components of the glutathione complex.  Holistically, we need to look at the whole process from beginning to end.

Here are some of the nutrients required:

Methyl B12: this is vitamin B12 in its “methyl” form (whether as a nose spray, subcutaneous injection, or orally) it aids in the process

Vitamin B6: aides in the production of glutathione.

Folic acid: this is B9 and it  works as a cofactor in the Methylation factory.

Dimethylglycine: also known as DMG.  DMG also supports the Methylation pathway as a “methyl donor”.

Trimethylglycine: also known as TMG.  TMG is DMG plus another methyl group.

Methionine: an amino acid that can be eventually transformed into glutathione

N-acetyl cysteine: also known as NAC.  The N-Acetyl provides a stabilizing mechanism for the unstable cysteine in glutathione – that we tend not to have enough of.

In addition to providing these supplements, you can take Protandim to turn on the DNA that makes the mRNA tools that manufacture glutathione.

You can also take OGF – the Original Glutathione Formula that Dr. Keller formulated that provides the nutrients necessary to make GSH.

You can also take glutathione injections – but glutathione is very short lived in the blood when taken this way and can cause other issues.

You can also go to a health practitioner and determine what you are deficient in and how to best provide it for your own body.

Be responsible, do your research, find a good health practitioner.

Here’s to your health!

For more information, contact: Dr Holly at

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